Eur. J. Entomol. 94 (2): 161-166, 1997

Biological effects of muristerone A and turkesterone on the epithelial cell line from Chironomus tentans (Diptera: Chironomidae) and correlation with binding affinity to the ecdysteroid receptor

SPINDLER-BARTH M., QUACK S., RAUCH P., SPINDLER K.-D.
N/A

Ecdysteroids, which possess an alpha-hydroxyl group at C11, bind with about the same affinity to the ecdysteroid receptor as compared to the corresponding compounds lacking the hydroxyl group. This is shown for turkesterone/20-hydroxyecdysone and muristerone A using receptor preparations from the epithelial cell line from Chironomus tentans. For all compounds tested, the potency to elicit a hormonal response corresponds with the affinity to the ecdysteroid receptor as determined by induction of acetylcholinesterase, a marker enzyme for cell differentiation.

Keywords: Muristerone A, turkesterone, ponasterone A, 20-OH-ecdysone, ecdysteroid receptor, insect cell line, acetylcholinesterase, Chironomidae, Chironomus tentans

Accepted: September 9, 1996; Published: May 15, 1997  Show citation

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SPINDLER-BARTH, M., QUACK, S., RAUCH, P., & K.-D., S. (1997). Biological effects of muristerone A and turkesterone on the epithelial cell line from Chironomus tentans (Diptera: Chironomidae) and correlation with binding affinity to the ecdysteroid receptor. EJE, 94(2), 161-166
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