Eur. J. Entomol. 96 (3): 323-326, 1999

Immunocytochemical distribution of angiotensin-I converting enzyme in the central nervous system of insects and speculations about its possible function

VEELAERT D., SCHOOFS L., MACOURS N., VANDINGENEN A., DE LOOF A., ISAAC E., SALZET M., HUYBRECHTS R.
N/A

Insect peptidyl-dipeptidase A [angiotensin I - converting enzyme (ACE)] is a soluble single-domain peptidyl-dipeptidase that has many properties in common with the C-domain of mammalian somatic ACE and with the single-domain mammalian ACE. In agreement with a variety of insects, immunocytochemical studies reveal the presence of an ACE-like protein in Locusta migratoria. ACE-like immunoreactivity is present in neurosecretory cells of the pars intercerebralis. These cells have axons projecting into the nervus corporis cardiaci I and into the storage part of the corpus cardiacum, a neuroendocrine organ directly releasing into the aorta. The localisation of ACE in neurosecretory cells is consistent with its proposed role as a processing enzyme that is involved in the generation of active peptide hormones.

Keywords: Insecta, Locusta migratoria, corpus cardiacum, pars intercerebralis, ACE, neuropeptide

Accepted: April 6, 1999; Published: October 25, 1999  Show citation

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VEELAERT, D., SCHOOFS, L., MACOURS, N., VANDINGENEN, A., DE LOOF, A., ISAAC, E., SALZET, M., & HUYBRECHTS, R. (1999). Immunocytochemical distribution of angiotensin-I converting enzyme in the central nervous system of insects and speculations about its possible function. EJE, 96(3), 323-326
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